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Ampicillin - General information

A special place in the t reatment of the infectious diseases takes Ampicillin drug. It is a worldwide semisynthetic antibiotic from the group of penicillin of broad spectrum action.

Ampicillin is one of the most active antibiotics with bactericidal type of the pharmacological action. the pharmacological action appears quickly because the active components of the drug are easily absorbed from the gastro-intestinal tract, and spread in most tissues and organs. After reaching the tissue and organs Ampicillin finds the morbific microorganisms and prevents the formation of their peptide (amino-acid) bonds. As a result, there is a destruction of the formation of the cell wall of bacteria and lysis of microorganisms.

Ampicillin is not destroyed in the acid environment of the stomach but is exposed to the destruction by B-lactamase, therefore, in many cases, patients may buy Ampicillin, have the course of the treatment but get rid of the infection not completely, because the part of the antibiotic will be destroyed.

Directions for the use Ampicillin

Ampicillin is prescribed for the treatment of the complicated infectious-inflammatory diseases caused by microorganisms sensitive to penicillin:  

  • Infections of the respiratory tracts and HENT-organs (pneumonia, abscess of lungs, bronchitis, sinusitis, tonsillitis, pharyngitis)
  • The inflammatory infections of kidneys and urination tracts (cystitis, pyelonephritis, pyelitis, urethritis)
  • Chlamydia
  • Meningitis
  • Infections of the skin and soft tissues (erysipelas, impetigo, infected dermatosis)
  • Infections of the motor apparatus
  • Acute infections of organs of Gastro-intestinal tract (typhoid fever, paratyphoid, dysentery, shigellosis, salmonella)

Ampicillin: Dosage details

Before you buy Ampicillin, take time to visit a physician for complete examination. If you know the exact diagnosis and type of the causative agent which caused the infection, it will be easier to struggle with this infection.

The dosage regimen may be adjusted in the process of the treatment depending on the severity of the course, site of the infection, and sensitivity of the causative agent.

  • Adults are recommended to start the treatment from the minimal dose of 250-500 mg 4 times a day
  • Children with the body weight under 20 kg are prescribed the dose according to the scheme: 12.5-25 mg per 1 kg of the body weight a day. The daily dosage is divided into 4 uses
  • The maximal peroral daily dosage for adults is 4 g (single dose of 1 g). The maximal dose may be taken for a short-period of time in order to avoid the overdose.
  • The length of the treatment is determined by the efficiency of the antibacterial therapy and disease severity. Usually, Ampicillin is taken within 5-10 days. For severe infectious processes the treatment may last for 2-3 weeks but with the use of lower doses.

Ampicillin: Side effects

A short use of Ampicillin in allowed doses does not cause the side effects in 99% of cases.

Light side effects may appear during the increased sensitivity to penicillin: headache, tremor, spasms, and pain in joints.

Interaction with other medical products

  • In order to avoid the destruction of Ampicillin by B-lactamase it is recommended to take this medicine with Sulbactam – inhibitor of B-lactamase
  • Ampicillin increases the action of the indirect anticoagulants inhibiting the intestinal microflora
  • Diuretics, phenylbutazone, NSAIDs stimulate the increase of Ampicillin in plasma of the blood.
  • Ampicillin reduces the efficiency of the hormone oral contraception.


In case of the overdose with Ampicillin drug there is a toxic action to the central nervous system and gastro-intestinal tract. So, the patient develop vivid symptoms such as nausea, vomiting, diarrhea, dehydration, dizziness, and hallucinations.

In case of the overdose it is needed to see a doctor as soon as possible and have the stomach lavage, and take measures to maintain water-electrolytic balance.

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Brand names include: Omnipen / Ampicyn / Penbritin / Rimacillin / Principen

Active ingredient: Ampicillin Class: Aminopenicillins.

Formulation Type :Capsules 250, 500 mg

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